Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1

Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to peroxisome for βoxidation, dysfunction of which causes the X-ALD. Here, the authors report three structures of ABCD1: the ligand-free, C22:0-CoA- and ATP-bound forms.

Bibliographic Details
Main Authors: Zhi-Peng Chen, Da Xu, Liang Wang, Yao-Xu Mao, Yang Li, Meng-Ting Cheng, Cong-Zhao Zhou, Wen-Tao Hou, Yuxing Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30974-5

Internet

https://doi.org/10.1038/s41467-022-30974-5

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