Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice

Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice

Abstract Purpose PAQR7 plays a key role in cell apoptosis as a progesterone membrane receptor. The physiological mechanism of PAQR7 in ovarian function and its anti-apoptotic action in mammals remain poorly understood. Methods We first added 0.2 µM aminoglutethimide (AG), an inhibitor of endogenous...

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Bibliographic Details
Main Authors: Jia Li, Yiting Liu, Jinxia He, Zixuan Wu, Fang Wang, Jian Huang, Liping Zheng, Tao Luo
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Ovarian Research
Subjects:
Apoptosis
Granulosa cell
Ovarian function
Progesterone
Progestin and adipoQ receptor 7(PAQR7)
Online Access:https://doi.org/10.1186/s13048-024-01348-w

Internet

https://doi.org/10.1186/s13048-024-01348-w

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