Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function

Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function

A key feature of RNA polymerase II (Pol II) preinitiation complexes (PICs) is their ability to coordinate transcription initiation with chromatin modification and remodeling. To understand how this coordination is achieved, we employed extensive proteomic and mechanistic analyses to study the compos...

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Bibliographic Details
Main Authors: Xiao-Fen Chen, Lynn Lehmann, Justin J. Lin, Ajay Vashisht, Ryan Schmidt, Roberto Ferrari, Chengyang Huang, Robin McKee, Amber Mosley, Kathrin Plath, Siavash K. Kurdistani, James Wohlschlegel, Michael Carey
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003749

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http://www.sciencedirect.com/science/article/pii/S2211124712003749

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