Stereoelectronic Features of a Complex Ketene Dimerization Reaction

Stereoelectronic Features of a Complex Ketene Dimerization Reaction

The amidation reaction of a tetrahydroisoquinolin-1-one-4-carboxylic acid is a key step in the multi-kilogram-scale preparation of the antimalarial drug SJ733, now in phase 2 clinical trials. In the course of investigating THIQ carboxamidations, we found that propanephosphonic acid anhydride (T3P) i...

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Bibliographic Details
Main Authors: Robert D. Barrows, Mark J. Dresel, Thomas J. Emge, Paul R. Rablen, Spencer Knapp
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
malaria
amidation
decarboxylation
decarbonylation
carbene insertion
arylketene
Online Access:https://www.mdpi.com/1420-3049/27/1/66

Internet

https://www.mdpi.com/1420-3049/27/1/66

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