Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties

Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties

Engineered bone graft designs have been largely inspired by adult bone despite functionally significant differences from the composition of anabolic bone in both the mineralized and non-mineralized fractions. Specifically, anabolic bone contains hydroxyapatite with ionic substitutions that facilitat...

Full description

Bibliographic Details
Main Authors: Eli Mondragón, Mitzy Cowdin, Francesca Taraballi, Silvia Minardi, Ennio Tasciotti, Carl A. Gregory, Roland Kaunas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stem cells
extracellular matrix
drug-delivery
bioreactor
bone
biomimetic
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00753/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00753/full

Similar Items