The Multifaceted Role of TGF-β in Gastrointestinal Tumors

The Multifaceted Role of TGF-β in Gastrointestinal Tumors

Transforming growth factor-beta (TGF-β) is a secreted cytokine that signals via serine/threonine kinase receptors and SMAD effectors. Although TGF-β acts as a tumor suppressor during the early stages of tumorigenesis, it supports tumor progression in advanced stages. Indeed, TGF-β can modulate the t...

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Bibliographic Details
Main Authors: Fabio Sabbadini, Monica Bertolini, Serena De Matteis, Domenico Mangiameli, Serena Contarelli, Silvia Pietrobono, Davide Melisi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
TGF-β
gastrointestinal tumors
EMT
targeted therapy
immune plasticity
Online Access:https://www.mdpi.com/2072-6694/13/16/3960

Internet

https://www.mdpi.com/2072-6694/13/16/3960

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