Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

Podrobná bibliografie
Hlavní autoři:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Médium:	Článek
Jazyk:	English
Vydáno:	Elsevier 2012-06-01
Edice:	Neurobiology of Disease
Témata:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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