Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Elsevier 2012-06-01
Cyfres:	Neurobiology of Disease
Pynciau:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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