Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

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מידע ביבליוגרפי
Main Authors:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
פורמט:	Article
שפה:	English
יצא לאור:	Elsevier 2012-06-01
סדרה:	Neurobiology of Disease
נושאים:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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