Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

書誌詳細
主要な著者:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
フォーマット:	論文
言語:	English
出版事項:	Elsevier 2012-06-01
シリーズ:	Neurobiology of Disease
主題:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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