Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

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Autors principals: S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Format: Article
Idioma:English
Publicat: Elsevier 2012-06-01
Col·lecció:Neurobiology of Disease
Matèries:
Huntingtin
Polyglutamine
Jab1
p27(Kip1)
Transcriptional deregulation
Accés en línia:http://www.sciencedirect.com/science/article/pii/S0969996112000794

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000794

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