Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

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Bibliografske podrobnosti
Main Authors: S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Format: Article
Jezik:English
Izdano: Elsevier 2012-06-01
Serija:Neurobiology of Disease
Teme:
Huntingtin
Polyglutamine
Jab1
p27(Kip1)
Transcriptional deregulation
Online dostop:http://www.sciencedirect.com/science/article/pii/S0969996112000794

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000794

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