A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

Targeted CRISPR libraries expand the use of genetic screens across experimental conditions. Here, the authors develop a method for generating and analysing small scale custom CRISPR libraries and use it in the human and livestock pathogen Toxoplasma gondii to identify virulence factors in mice.

Bibliográfalaš dieđut
Váldodahkkit: Joanna Young, Caia Dominicus, Jeanette Wagener, Simon Butterworth, Xingda Ye, Gavin Kelly, Merav Ordan, Becky Saunders, Rachael Instrell, Michael Howell, Aengus Stewart, Moritz Treeck
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Nature Portfolio 2019-09-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-019-11855-w

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