Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease

Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease

The critical discovery of the presenilins and their association with familial Alzheimer’s disease (AD) prompted an intensive research effort to understand the molecular mechanisms of that disease. The presenilins were subsequently found to be the catalytic component of the multi-protein enzyme compl...

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Bibliographic Details
Main Authors: Caroline Coleman-Vaughan, Indu Patwal, Justin V. McCarthy, Tara P. Hurst
Format: Article
Language:English
Published: AIMS Press 2016-04-01
Series:AIMS Molecular Science
Subjects:
Presenilin
gamma-secretase (γ-secretase)
regulated intramembrane proteolysis
Alzheimer’s disease (AD)
innate immune system
neuroinflammation
Online Access:http://www.aimspress.com/Molecular/article/749/fulltext.html

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http://www.aimspress.com/Molecular/article/749/fulltext.html

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