Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease
The critical discovery of the presenilins and their association with familial Alzheimer’s disease (AD) prompted an intensive research effort to understand the molecular mechanisms of that disease. The presenilins were subsequently found to be the catalytic component of the multi-protein enzyme compl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-04-01
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| Series: | AIMS Molecular Science |
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| Online Access: | http://www.aimspress.com/Molecular/article/749/fulltext.html |
| _version_ | 1818472018949963776 |
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| author | Caroline Coleman-Vaughan Indu Patwal Justin V. McCarthy Tara P. Hurst |
| author_facet | Caroline Coleman-Vaughan Indu Patwal Justin V. McCarthy Tara P. Hurst |
| author_sort | Caroline Coleman-Vaughan |
| collection | DOAJ |
| description | The critical discovery of the presenilins and their association with familial Alzheimer’s disease (AD) prompted an intensive research effort to understand the molecular mechanisms of that disease. The presenilins were subsequently found to be the catalytic component of the multi-protein enzyme complex, γ-secretase, the enzyme that is known to act on the amyloid precursor protein (APP) to generate amyloid beta (Aβ) peptides that comprise the neuritic plaques implicated in AD pathology. Here, we discuss the background of γ-secretase- mediated proteolysis of APP and its association with familial AD. We discuss the association of neuroinflammation with AD, focusing on the link between the innate immune response, the clearance of the Aβ peptides and disease progression. Currently, there are limited treatments for AD that strive to ameliorate the symptoms of the disease but do not address the molecular basis of the disease. The greater understanding of γ- secretase functions has provided new insights into potential therapeutics for AD, a number of which are in clinical trials. |
| first_indexed | 2024-04-14T03:59:50Z |
| format | Article |
| id | doaj.art-ff7ed68ee5cc460bb65d21fe54c3abd8 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-04-14T03:59:50Z |
| publishDate | 2016-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-ff7ed68ee5cc460bb65d21fe54c3abd82022-12-22T02:13:38ZengAIMS PressAIMS Molecular Science2372-03012016-04-013213815710.3934/molsci.2016.2.138molsci-03-00138Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s diseaseCaroline Coleman-Vaughan0Indu Patwal1Justin V. McCarthy2Tara P. HurstSignal Transduction Laboratory, School of Biochemistry & Cell Biology, ABCRF, Western Gateway Building, Western Road, University College Cork, Cork, IrelanSignal Transduction Laboratory, School of Biochemistry & Cell Biology, ABCRF, Western Gateway Building, Western Road, University College Cork, Cork, IrelanSignal Transduction Laboratory, School of Biochemistry & Cell Biology, ABCRF, Western Gateway Building, Western Road, University College Cork, Cork, IrelanThe critical discovery of the presenilins and their association with familial Alzheimer’s disease (AD) prompted an intensive research effort to understand the molecular mechanisms of that disease. The presenilins were subsequently found to be the catalytic component of the multi-protein enzyme complex, γ-secretase, the enzyme that is known to act on the amyloid precursor protein (APP) to generate amyloid beta (Aβ) peptides that comprise the neuritic plaques implicated in AD pathology. Here, we discuss the background of γ-secretase- mediated proteolysis of APP and its association with familial AD. We discuss the association of neuroinflammation with AD, focusing on the link between the innate immune response, the clearance of the Aβ peptides and disease progression. Currently, there are limited treatments for AD that strive to ameliorate the symptoms of the disease but do not address the molecular basis of the disease. The greater understanding of γ- secretase functions has provided new insights into potential therapeutics for AD, a number of which are in clinical trials.http://www.aimspress.com/Molecular/article/749/fulltext.htmlPresenilingamma-secretase (γ-secretase)regulated intramembrane proteolysisAlzheimer’s disease (AD)innate immune systemneuroinflammation |
| spellingShingle | Caroline Coleman-Vaughan Indu Patwal Justin V. McCarthy Tara P. Hurst Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease AIMS Molecular Science Presenilin gamma-secretase (γ-secretase) regulated intramembrane proteolysis Alzheimer’s disease (AD) innate immune system neuroinflammation |
| title | Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease |
| title_full | Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease |
| title_fullStr | Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease |
| title_full_unstemmed | Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease |
| title_short | Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease |
| title_sort | regulated intramembrane proteolysis innate immunity and therapeutic targets in alzheimer s disease |
| topic | Presenilin gamma-secretase (γ-secretase) regulated intramembrane proteolysis Alzheimer’s disease (AD) innate immune system neuroinflammation |
| url | http://www.aimspress.com/Molecular/article/749/fulltext.html |
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