FL118, acting as a ‘molecular glue degrader’, binds to, dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy

FL118, acting as a ‘molecular glue degrader’, binds to, dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy

ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC), a difficult‐to‐treat cancer, is expected to become the second‐largest cause of cancer‐related deaths by 2030, while colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer deaths. Currently, there is n...

Full description

Bibliographic Details
Main Authors: Xiang Ling, Wenjie Wu, Ieman A. M. Aljahdali, Jianqun Liao, Sreevidya Santha, Christos Fountzilas, Patrick M. Boland, Fengzhi Li
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Clinical and Translational Medicine
Subjects:
c‐Myc
colorectal cancer (CRC)
DDX5/p68
FL118
human tumour animal models
mutant Kras (mKras)
Online Access:https://doi.org/10.1002/ctm2.881

Internet

https://doi.org/10.1002/ctm2.881

Similar Items