Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells

Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells

Abstract Background Heterotopic ossification (HO) can limit joint activity, causes ankylosis and impairs the function and rehabilitation of patients. Endothelial to mesenchymal transition (EndMT) plays an important role in the pathogenesis of HO, and high expression of SMAD7(Mothers Against Decapent...

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Bibliographic Details
Main Authors: Zhenyuan Wei, Yang Zhao, Peichun Hsu, Shang Guo, Chi Zhang, Biao Zhong
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Gene therapy
SMAD7
exosome
endothelial-mesenchymal transition
mouse aortic endothelial cells
endothelial cell targeting property
Online Access:https://doi.org/10.1186/s12891-021-04896-0

Internet

https://doi.org/10.1186/s12891-021-04896-0

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