Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery

Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery

Maintenance of genomic integrity is crucial for cell survival. As such, elegant DNA damage response (DDR) systems have evolved to ensure proper repair of DNA double-strand breaks (DSBs) and other lesions that threaten genomic integrity. Towards this end, most therapeutic studies have focused on unde...

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Bibliographic Details
Main Authors: Thomas J. Hayman, Peter M. Glazer
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage response
STING
cGAS
DNA repair
radiation
innate immune system
Online Access:https://www.mdpi.com/1422-0067/22/23/12761

Internet

https://www.mdpi.com/1422-0067/22/23/12761

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