New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfo...

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Bibliographic Details
Main Authors: Nona Pooryaghoobi, Mehdi Bakavoli, Maliheh Alimardani, Tahmineh Bazzazan, Hamid Sadeghian
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2013-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
DMAB Docking MBTH Peroxide formation SLO
Online Access:http://ijbms.mums.ac.ir/pdf_995_502ede5bb774011db826c603853ac16a.html

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http://ijbms.mums.ac.ir/pdf_995_502ede5bb774011db826c603853ac16a.html

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