S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4

Abstract Members of the S100 protein family have been reported to function as endogenous danger signals (alarmins) playing an active role in tissue inflammation and repair when released from necrotic cells. Here, we investigated the role of S100A1, the S100 isoform with highest abundance in cardiomy...

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Bibliographic Details
Main Authors: David Rohde, Christoph Schön, Melanie Boerries, Ieva Didrihsone, Julia Ritterhoff, Katharina F Kubatzky, Mirko Völkers, Nicole Herzog, Mona Mähler, James N Tsoporis, Thomas G Parker, Björn Linke, Evangelos Giannitsis, Erhe Gao, Karsten Peppel, Hugo A Katus, Patrick Most
Format: Article
Language:English
Published: Springer Nature 2014-06-01
Series:EMBO Molecular Medicine
Subjects:
alarmin
cardiac fibroblast
damage‐associated molecular pattern (DAMP)
S100A1
Toll‐like receptors (TLRs)
Online Access:https://doi.org/10.15252/emmm.201303498

Internet

https://doi.org/10.15252/emmm.201303498

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