Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades

Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades

<p>Abstract</p> <p>Background</p> <p>The membrane-bound mucins are thought to play an important biological role in cell–cell and cell–matrix interactions, in cell signaling and in modulating biological properties of cancer cell. MUC4, a transmembrane mucin is overexpres...

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Bibliographic Details
Main Authors: Kunigal Sateesh, Ponnusamy Moorthy P, Momi Navneet, Batra Surinder K, Chellappan Srikumar P
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Cancer
Subjects:
Mucin 4
Pancreatic cancer
Cell proliferation and invasion invasion
Src Kinase
Akt pathway.
Online Access:http://www.molecular-cancer.com/content/11/1/24

Internet

http://www.molecular-cancer.com/content/11/1/24

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