Street RABV Induces the Cholinergic Anti-inflammatory Pathway in Human Monocyte-Derived Macrophages by Binding to nAChr α7

Street RABV Induces the Cholinergic Anti-inflammatory Pathway in Human Monocyte-Derived Macrophages by Binding to nAChr α7

Rabies virus (RABV) is able to reach the central nervous system (CNS) without triggering a strong immune response, using multiple mechanisms to evade and suppress the host immune system. After infection via a bite or scratch from a rabid animal, RABV comes into contact with macrophages, which are th...

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Bibliographic Details
Main Authors: Carmen W. E. Embregts, Lineke Begeman, Cees J. Voesenek, Byron E. E. Martina, Marion P. G. Koopmans, Thijs Kuiken, Corine H. GeurtsvanKessel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
rabies
lyssaviruses
monocyte-derived macrophages
innate immunity
immunosuppression
cholinergic anti-inflammatory pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.622516/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.622516/full

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