Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression

<p>Abstract</p> <p>Background</p> <p>The T cell antigen receptors (TCR) of αβ and γδ T lymphocytes are believed to assemble in a similar fashion in humans. Firstly, αβ or γδ TCR chains incorporate a CD3δε dimer, then a CD3γε dimer and finally a ζζ homodimer, resulting i...

Full description

Bibliographic Details
Main Authors: Muñoz-Ruiz Miguel, Pérez-Flores Verónica, Garcillán Beatriz, Guardo Alberto C, Mazariegos Marina S, Takada Hidetoshi, Allende Luis M, Kilic Sara S, Sanal Ozden, Roifman Chaim M, López-Granados Eduardo, Recio María J, Martínez-Naves Eduardo, Fernández-Malavé Edgar, Regueiro José R
Format: Article
Language:English
Published: BMC 2013-01-01
Series:BMC Immunology
Subjects:
T cells
CD3
Haploinsufficiency
Online Access:http://www.biomedcentral.com/1471-2172/14/3

Internet

http://www.biomedcentral.com/1471-2172/14/3

Similar Items