EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models

EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models

Nasopharyngeal carcinoma (NPC), is an Epstein-Barr virus (EBV) associated malignancy most common in Southern China and Southeast Asia. In southern China, it is one of the major causes of cancer-related death. Despite improvement in radiotherapy and chemotherapy techniques, locoregional recurrence an...

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Bibliographic Details
Main Authors: Yanru Guo, Saidu Kamara, Jing Zhang, He Wen, Maolin Zheng, Ying Liu, Luqi Zhou, Jun Chen, Shanli Zhu, Lifang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
EBV
LMP1
affibody molecules
nasopharyngeal carcinoma
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1078504/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1078504/full

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