TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression

TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression

Clinical and molecular heterogeneity are hallmarks of chronic lymphocytic leukemia (CLL), a neoplasm characterized by accumulation of mature and clonal long-lived CD5 + B-lymphocytes. Mutational status of the IgHV gene of leukemic clones is a powerful prognostic tool in CLL, and it is well establish...

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Bibliographic Details
Main Authors: Maria Elena Marquez, Sandra Sernbo, Eugenia Payque, Rita Uria, Juan Pablo Tosar, Juliana Querol, Catalina Berca, Angimar Uriepero, Daniel Prieto, Diego Alvarez-Saravia, Carolina Oliver, Victoria Irigoin, Gimena Dos Santos, Cecilia Guillermo, Ana Inés Landoni, Marcelo Navarrete, Florencia Palacios, Pablo Oppezzo
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
chronic lymphocytic leukemia
microenvironment
microRNAs
TGF-β/SMAD pathway
Online Access:https://www.mdpi.com/2072-6694/14/7/1676

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https://www.mdpi.com/2072-6694/14/7/1676

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