SHP2 potentiates anti-PD-1 effectiveness through intervening cell pyroptosis resistance in triple-negative breast cancer

SHP2 potentiates anti-PD-1 effectiveness through intervening cell pyroptosis resistance in triple-negative breast cancer

Triple negative breast cancer (TNBC) presents a formidable challenge due to the lack of effective treatment modalities. Immunotherapy stands as a promising therapeutic approach; however, the emergence of drug resistance mechanisms within tumor cells, particularly those targeting apoptosis and pyropt...

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Bibliographic Details
Main Authors: Chao Chen, Yuanyuan Cheng, Haoqi Lei, Xuefei Feng, Hongxia Zhang, Lingling Qi, Jufeng Wan, Haiying Xu, Xin Zhao, Yan Zhang, Baofeng Yang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
TNBC
SHP2
JNK
Pyroptosis resistance
PD-1
GSDMD
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223015950

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http://www.sciencedirect.com/science/article/pii/S0753332223015950

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