STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma

STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma

Summary: The dysregulation of glutamine metabolism provides survival advantages for tumors by supplementing tricarboxylic acid cycle. Glutamate dehydrogenase 1 (GLUD1) is one of the key enzymes in glutamine catabolism. Here, we found that enhanced protein stability was the key factor for the upregul...

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Bibliographic Details
Main Authors: Qifan Hu, Jiapeng Lei, Zhujun Cheng, Jing Xu, Lei Wang, Yi Yuan, Mingxi Gan, Yanan Wang, Yilin Xie, Lu Yao, Keru Wang, Yuhan Liu, Wenze Xun, Jian-Bin Wang, Tianyu Han
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012282

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http://www.sciencedirect.com/science/article/pii/S2589004223012282

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