Bioreactor Parameters for Microcarrier-Based Human MSC Expansion under Xeno-Free Conditions in a Vertical-Wheel System

Human mesenchymal stem/stromal cells (hMSCs) have been investigated and proven to be a well-tolerated, safe therapy for a variety of indications, as shown by over 900 registered hMSC-based clinical trials. To meet the commercial demand for clinical manufacturing of hMSCs, production requires a scale...

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Bibliographic Details
Main Authors: Josephine Lembong, Robert Kirian, Joseph D. Takacs, Timothy R. Olsen, Lye Theng Lock, Jon A. Rowley, Tabassum Ahsan
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Bioengineering
Subjects:
Online Access:https://www.mdpi.com/2306-5354/7/3/73