A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

Abstract Background The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns over the course. Here, we analyze the temporal patte...

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Bibliographic Details
Main Authors: Michael Rade, Sebastian Böhlen, Vanessa Neuhaus, Dennis Löffler, Conny Blumert, Maximilian Merz, Ulrike Köhl, Susann Dehmel, Katherina Sewald, Kristin Reiche
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Biology
Subjects:
T-cell activation
Non-negative matrix factorization
Transcriptome
Gene expression
Temporal gene profiles
Biomarkers
Online Access:https://doi.org/10.1186/s13059-023-03120-7

Internet

https://doi.org/10.1186/s13059-023-03120-7

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