Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an...

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Bibliographic Details
Main Authors: Indumathi Manoharan, Puttur D. Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.691134/full