Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely prescribed for hyperlipidemia management. Recent studies also showed that it has therapeutic potential in various liver diseases. However, its effects on hepatomegaly and liver regeneration and the involved mechan...

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Bibliographic Details
Main Authors: Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Fenofibrate
PPARα
Hepatomegaly
Partial hepatectomy
Liver regeneration
YAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524001230

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http://www.sciencedirect.com/science/article/pii/S2211383524001230

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