A genetic model for central chondrosarcoma evolution correlates with patient outcome

A genetic model for central chondrosarcoma evolution correlates with patient outcome

Abstract Background Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presence and absence of IDH1 and IDH2 mutations,...

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Main Authors: William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna-Christina Strobl, Christopher Davies, Sara Waise, Shadi Hames-Fathi, Dahmane Oukrif, Hongtao Ye, Fernanda Amary, Roberto Tirabosco, Craig Gerrand, Toby Baker, David Barnes, Christopher Steele, Ludmil Alexandrov, Gareth Bond, Genomics England Research Consortium, Paul Cool, Nischalan Pillay, Peter Van Loo, Adrienne M. Flanagan
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Medicine
Subjects:
Chondrosarcoma
Sarcoma
Genetics
Genomics
Cancer evolution
IDH1
Online Access:https://doi.org/10.1186/s13073-022-01084-0

Internet

https://doi.org/10.1186/s13073-022-01084-0

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