The power and the promise of synthetic lethality for clinical application in cancer treatment

The power and the promise of synthetic lethality for clinical application in cancer treatment

Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic in the field of targeted cancer therapy...

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Bibliographic Details
Main Authors: Qian-Wen Liu, Zhi-Wen Yang, Qing-Hai Tang, Wen-Er Wang, Da-Sheng Chu, Jin-Feng Ji, Qi-Yu Fan, Hong Jiang, Qin-Xin Yang, Hui Zhang, Xin-Yun Liu, Xiao-Sheng Xu, Xiao-Feng Wang, Ji-Bin Liu, Da Fu, Kun Tao, Hong Yu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Synthetic lethality
Cancer
Drug
DNA repair
Clinical application
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001690

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http://www.sciencedirect.com/science/article/pii/S0753332224001690

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