Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

Natural killer (NK) cells are attractive effectors for adoptive immunotherapy of cancer. Results from first-in-human studies using chimeric antigen receptor (CAR)-engineered primary NK cells and NK-92 cells are encouraging in terms of efficacy and safety. In order to further improve treatment strate...

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Bibliographic Details
Main Authors: Nivedha Murali Shankar, Paola Ortiz-Montero, Anastasia Kurzyukova, Wiebke Rackwitz, Stephan R. Künzel, Winfried S. Wels, Torsten Tonn, Franziska Knopf, Jiri Eitler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
CAR-NK cells
zebrafish xenograft
cancer immunotherapy
NK-92
PD-L1
ErbB2 (HER2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1254821/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1254821/full

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