Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients

Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients

Human papillomavirus (HPV)-driven head and neck squamous cell carcinomas (HNSCC) generally have a more favourable prognosis. We hypothesized that HPV-associated HNSCC may be identified by an miRNA-signature according to their specific molecular pathogenesis, and be characterized by a unique transcri...

Full description

Bibliographic Details
Main Authors: Julia Hess, Kristian Unger, Cornelius Maihoefer, Lars Schüttrumpf, Peter Weber, Sebastian Marschner, Ludmila Wintergerst, Ulrike Pflugradt, Philipp Baumeister, Axel Walch, Christine Woischke, Thomas Kirchner, Martin Werner, Kristin Sörensen, Michael Baumann, Ingeborg Tinhofer, Stephanie E. Combs, Jürgen Debus, Henning Schäfer, Mechthild Krause, Annett Linge, Jens von der Grün, Martin Stuschke, Daniel Zips, Martin Canis, Kirsten Lauber, Ute Ganswindt, Michael Henke, Horst Zitzelsberger, Claus Belka
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
head and neck cancer
HNSCC
HPV
miRNA
signature
prediction
Online Access:https://www.mdpi.com/2072-6694/14/15/3745

Internet

https://www.mdpi.com/2072-6694/14/15/3745

Similar Items