The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.

The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.

Differentiation signaling results in reprogramming of cellular gene expression that leads to morphological changes and functional specialization of a precursor cell. This global change in gene expression involves temporal regulation of differentiation-specific genes that are located throughout the g...

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Bibliographic Details
Main Authors: Scott E LeBlanc, Qiong Wu, A Rasim Barutcu, Hengyi Xiao, Yasuyuki Ohkawa, Anthony N Imbalzano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3896465?pdf=render

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http://europepmc.org/articles/PMC3896465?pdf=render

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