Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions

Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions

Abstract Background TMC1, which encodes transmembrane channel-like protein 1, forms the mechanoelectrical transduction (MET) channel in auditory hair cells, necessary for auditory function. TMC1 variants are known to cause autosomal dominant (DFNA36) and autosomal recessive (DFNB7/11) non-syndromic...

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Bibliographic Details
Main Authors: Sung Ho Cho, Yejin Yun, Dae Hee Lee, Joo Hyun Cha, So Min Lee, Jehyun Lee, Myung Hwan Suh, Jun Ho Lee, Seung-Ha Oh, Moo Kyun Park, Sang-Yeon Lee
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Medical Genomics
Subjects:
TMC1
Hearing loss
Structural modeling
DFNA36
Protein-lipid interaction
Online Access:https://doi.org/10.1186/s12920-023-01766-7

Internet

https://doi.org/10.1186/s12920-023-01766-7

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