Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory

Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory

The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP belongs to a small gene family, including besides APP the closely related amyloid precursor-like proteins APLP1 and APLP2, that all constitu...

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Bibliographic Details
Main Authors: Susanne Erdinger, Irmgard Amrein, Michaela Back, Susann Ludewig, Martin Korte, Jakob von Engelhardt, David P. Wolfer, Ulrike C. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer disease
APP
APLP1
amyloid precursor like protein
synaptic plasticity
behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1028836/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1028836/full

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