The Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells

The Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells

Purpose: Hypoxia plays an essential role in the progression of hepatocellular carcinoma (HCC), whereas hypoxia inducible factor-1 (HIF-1) is the key transcription factor allowing HCC to survive hypoxia. The aim of this study was to define the essential mRNAs and miRNAs regulated by HIF1A and dissect...

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Bibliographic Details
Main Authors: Tong Liu, Jing Tang, Xiaoyu Li, Yuan Lin, Yuma Yang, Kai Ma, Zhaoyuan Hui, Hong Ma, Yanyan Qin, Hetian Lei, Yanhui Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Genetics
Subjects:
HIF1A
CRISPR/Cas9
HepG2
mRNA-seq
miRNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.857507/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.857507/full

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