Environmental carbon tetrachloride exposure disrupts the liver structure and metabolic detoxification function in mice via p38MAPK/NF-κB/NLRP3 pathway

Environmental carbon tetrachloride exposure disrupts the liver structure and metabolic detoxification function in mice via p38MAPK/NF-κB/NLRP3 pathway

We investigated the effects of carbon tetrachloride (CCl4) exposure on liver detoxification. We confirmed that 0.2%-0.8% CCl4 decreased the liver carboxylesterase (CarE), lactate dehydrogenase (LDH) activity and total protein (TP) levels, while 0.2% and 0.8% CCl4 increased the liver acetylcholine es...

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Bibliographic Details
Main Authors: Yuanyuan Wei, Danyang Ma, Yimeng Fan, Chen Gao, Qingtao Wang, Yanyan Yuan, Yannan Zhang, Juncheng Han, Zhihui Hao
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Food and Agricultural Immunology
Subjects:
Carbon tetrachloride
liver injury
antioxidant
inflammation
network toxicology
Online Access:https://www.tandfonline.com/doi/10.1080/09540105.2022.2060192

Internet

https://www.tandfonline.com/doi/10.1080/09540105.2022.2060192

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