Schistosoma mansoni Coinfection Attenuates Murine Toxoplasma gondii-Induced Crohn's-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response

Schistosoma mansoni Coinfection Attenuates Murine Toxoplasma gondii-Induced Crohn's-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response

Background and aims: Mice orally infected with T. gondii develop Crohn's disease (CD)-like enteritis associated with severe mucosal damage and a systemic inflammatory response, resulting in high morbidity and mortality. Previously, helminthic infections have shown therapeutic potential in exper...

Full description

Bibliographic Details
Main Authors: Beatriz Pêgo, Cesonia A. Martinusso, Claudio Bernardazzi, Beatriz Elias Ribeiro, Aline Fernandes de Araujo Cunha, Jacilene de Souza Mesquita, Hayandra F. Nanini, Marcelo Pelajo Machado, Morgana T. L. Castelo-Branco, Marta Guimarães Cavalcanti, Heitor S. P. de Souza
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
S. mansoni coinfection
T. gondii-induced ileitis
mucosal immunity
Paneth cells
intestinal epithelial barrier
Crohn's disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00442/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00442/full

Similar Items