Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation

Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation

Summary: Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, in antiviral immunity remains poorly defined. Here, we show that Parkin, a central player in mitophagy,...

Full description

Bibliographic Details
Main Authors: Jian Li, Chunmei Ma, Fei Long, Dongxue Yang, Xue Liu, Yingchao Hu, Chunyan Wu, Bingwei Wang, Min Wang, Yunzi Chen, Genyan Liu, Paul N. Moynagh, Jiawei Zhou, Tao Peng, Shuo Yang
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219301907

Internet

http://www.sciencedirect.com/science/article/pii/S2589004219301907

Similar Items