Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model

Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model

Bone health-targeting drug development strategies still largely rely on inferior 2D in vitro screenings. We aimed at developing a scaffold-free progenitor cell-based 3D biomineralization model for more physiological high-throughput screenings. MC3T3-E1 pre-osteoblasts were cultured in α-MEM with 10%...

Full description

Bibliographic Details
Main Authors: Maximilian Koblenzer, Marek Weiler, Athanassios Fragoulis, Stephan Rütten, Thomas Pufe, Holger Jahr
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
spheroid culture
osteoblast progenitors
MC3T3-E1
osteogenic differentiation
physiological biomineralization
volumetric micro-CT quantification
Online Access:https://www.mdpi.com/2073-4409/11/17/2702

Internet

https://www.mdpi.com/2073-4409/11/17/2702

Similar Items