Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

Abstract Background Lipoprotein(a) [LP(a)] is implicated as a common and independent risk factor for cardiovascular diseases. The therapeutic options currently available for reducing plasma LP(a) concentrations are limited. Diallyl disulphide (DADS), the main component of garlic, regulates lipid met...

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Bibliographic Details
Main Authors: Xiaofeng Ma, Yami Liu, Yanmei Tan, Kai Qu, Xinglan He, Hai Zhang, Zuo Wang
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Lipids in Health and Disease
Subjects:
Lipoprotein(a)
Apolipoprotein(a)
Diallyl disulfide
Extracellular regulated protein kinases
Mitogen-activated protein kinases
HepG2 cell
Online Access:http://link.springer.com/article/10.1186/s12944-017-0616-1

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http://link.springer.com/article/10.1186/s12944-017-0616-1

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