Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron

Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron

Summary: Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood. To address this, we performed proteomics and RNA-sequenci...

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Bibliographic Details
Main Authors: Allison L. Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A. Paulo, Beata Małachowska, Xia Xiao, Wojciech Fendler, Joseph D. Mancias, Jodie L. Babitt
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Integrative aspects of cell biology
Specialized functions of cells
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026329

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http://www.sciencedirect.com/science/article/pii/S2589004223026329

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