Parasitic nematode secreted phospholipase A2 suppresses cellular and humoral immunity by targeting hemocytes in Drosophila melanogaster

Parasitic nematode secreted phospholipase A2 suppresses cellular and humoral immunity by targeting hemocytes in Drosophila melanogaster

A key aspect of parasitic nematode infection is the nematodes’ ability to evade and/or suppress host immunity. This immunomodulatory ability is likely driven by the release of hundreds of excretory/secretory proteins (ESPs) during infection. While ESPs have been shown to display immunosuppressive ef...

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Bibliographic Details
Main Authors: Sophia C. Parks, Ogadinma K. Okakpu, Pakeeza Azizpor, Susan Nguyen, Stephanie Martinez-Beltran, Isaiah Claudio, Kyle Anesko, Anil Bhatia, Harpal S. Dhillon, Adler R. Dillman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
sPLA2
Steinernema carpocapsae
immune modulation
Drosophila
host-parasite interactions
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122451/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122451/full

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