pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles

pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles

Abstract Background A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pathogen Listeria monocytogenes has developed a s...

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Bibliographic Details
Main Authors: Ismael Plaza-GA, Vanesa Manzaneda-González, Matic Kisovec, Víctor Almendro-Vedia, Mónica Muñoz-Úbeda, Gregor Anderluh, Andrés Guerrero-Martínez, Paolo Natale, Iván López Montero
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Nanobiotechnology
Subjects:
Nanoparticles
Lysosomal escape
Listeriolysin O toxin
Quantum dots
Drug delivery
Online Access:http://link.springer.com/article/10.1186/s12951-019-0543-6

Internet

http://link.springer.com/article/10.1186/s12951-019-0543-6

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