DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype

DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype

Summary: Tumor relapse is linked to rapid chemoresistance and represents a bottleneck for cancer therapy success. Engagement of a reduced proliferation state is a non-mutational mechanism exploited by cancer cells to bypass therapy-induced cell death. Through combining functional pulse-chase experim...

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Bibliographic Details
Main Authors: Estefania Cuesta-Borràs, Cándida Salvans, Oriol Arqués, Irene Chicote, Lorena Ramírez, Laia Cabellos, Jordi Martínez-Quintanilla, Alex Mur-Espinosa, Alejandro García-Álvarez, Jorge Hernando, Juan Ramón Tejedor, Oriol Mirallas, Elena Élez, Mario F. Fraga, Josep Tabernero, Paolo Nuciforo, Jaume Capdevila, Héctor G. Palmer, Isabel Puig
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009385

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http://www.sciencedirect.com/science/article/pii/S2211124723009385

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