Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects

Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects

Summary: A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopathy. A principal regulator of cardiac metabolism i...

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Bibliographic Details
Main Authors: Maria F. Mendez Garcia, Satoshi Matsuzaki, Albert Batushansky, Ryan Newhardt, Caroline Kinter, Yan Jin, Shivani N. Mann, Michael B. Stout, Haiwei Gu, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Physiology
Molecular biology
Proteomics
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012087

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223012087

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