Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons
Summary: A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetic...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719316444 |
| _version_ | 1818067333018550272 |
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| author | Ayelén I. Groisman Sung M. Yang Alejandro F. Schinder |
| author_facet | Ayelén I. Groisman Sung M. Yang Alejandro F. Schinder |
| author_sort | Ayelén I. Groisman |
| collection | DOAJ |
| description | Summary: A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetics to study synaptogenesis between new GCs and GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs). PV-INs target the soma, and synapses become mature after 6 weeks. This transition is accelerated by exposure to an enriched environment. PV-INs exert efficient control of GC spiking and participate in both feedforward and feedback loops, a mechanism that would favor lateral inhibition and sparse coding. SST-INs target the dendrites, and synapses mature after 8 weeks. Outputs from GCs onto PV-INs develop faster than those onto SST-INs. Our results reveal a long-lasting transition wherein adult-born neurons remain poorly coupled to inhibition, which might enhance activity-dependent plasticity of input and output synapses. : Groisman et al. examine the integration of adult-born granule cells (GCs) to inhibitory networks of the adult hippocampus. Synapse maturation is remarkably slow for parvalbumin and somatostatin interneurons, both for connections toward and from GCs. Inhibition controls the activity of new GCs late in development. Keywords: inhibition, excitation |
| first_indexed | 2024-12-10T15:22:00Z |
| format | Article |
| id | doaj.art-ffdf01f2b6dd4800b878f9f95705d65d |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-10T15:22:00Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-ffdf01f2b6dd4800b878f9f95705d65d2022-12-22T01:43:39ZengElsevierCell Reports2211-12472020-01-01301202214.e4Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin InterneuronsAyelén I. Groisman0Sung M. Yang1Alejandro F. Schinder2Laboratorio de Plasticidad Neuronal, Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, ArgentinaLaboratorio de Plasticidad Neuronal, Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, ArgentinaLaboratorio de Plasticidad Neuronal, Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina; Corresponding authorSummary: A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetics to study synaptogenesis between new GCs and GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs). PV-INs target the soma, and synapses become mature after 6 weeks. This transition is accelerated by exposure to an enriched environment. PV-INs exert efficient control of GC spiking and participate in both feedforward and feedback loops, a mechanism that would favor lateral inhibition and sparse coding. SST-INs target the dendrites, and synapses mature after 8 weeks. Outputs from GCs onto PV-INs develop faster than those onto SST-INs. Our results reveal a long-lasting transition wherein adult-born neurons remain poorly coupled to inhibition, which might enhance activity-dependent plasticity of input and output synapses. : Groisman et al. examine the integration of adult-born granule cells (GCs) to inhibitory networks of the adult hippocampus. Synapse maturation is remarkably slow for parvalbumin and somatostatin interneurons, both for connections toward and from GCs. Inhibition controls the activity of new GCs late in development. Keywords: inhibition, excitationhttp://www.sciencedirect.com/science/article/pii/S2211124719316444 |
| spellingShingle | Ayelén I. Groisman Sung M. Yang Alejandro F. Schinder Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons Cell Reports |
| title | Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons |
| title_full | Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons |
| title_fullStr | Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons |
| title_full_unstemmed | Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons |
| title_short | Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons |
| title_sort | differential coupling of adult born granule cells to parvalbumin and somatostatin interneurons |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719316444 |
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